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Search Results for " cc chemokine receptor "

20

Compounds

Cat No. Product Name Synonyms Targets
T11481 GSK2239633A CCR
GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.
T4300 AZD2098 CCR
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
TQ0103 INCB3344 CCR
INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM (mCCR2) and in 3.8 nM (hCCR2) antagonism of chemotaxis act...
T4674 SB297006 SB 297006 CCR
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of ...
TQ0283 RS102895 CCR
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
T5384 RS 504393 CCR
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
T24700 R243 R 243,R-243 CCR
R243 is CCR8 signaling and chemotaxis inhibitor.
T30258 AZD-4818 CCR1 antagonist CCR
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.
T6413 Bindarit AF2838 CCR
Bindarit (AF2838) displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
T7499 TAK-779 Takeda 779 HIV Protease , CXCR , CCR
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
T16111 ML604086 CCR
ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 binding to CCR8 on circulating T-cells.
T10425 AZ084 CCR
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T16091 MK-0812 Succinate Others , CCR
MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2.
T11699 J-113863 CCR
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor...
T3430 PF-4136309 INCB8761,PF 4136309 CCR
PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.
T17225 Vercirnon CCX282-B,GSK-1605786,Traficet-EN CCR
Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
T4584 BMS-813160 BMS 813160 CCR
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T12773 RS102895 hydrochloride Others , 5-HT Receptor , CCR
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T2375 BX471 BX 471,BX-471,ZK-811752 CCR
BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.
T10639 C-021 dihydrochloride CCR
C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.
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